Journal article
Illuminating the biochemical interaction of antimicrobial few-layer black phosphorus with microbial cells using synchrotron macro-ATR-FTIR
ZL Shaw, S Cheeseman, LZY Huang, R Penman, T Ahmed, SJ Bryant, G Bryant, AJ Christofferson, R Orrell-Trigg, C Dekiwadia, VK Truong, JP Vongsvivut, S Walia, A Elbourne
Journal of Materials Chemistry B | ROYAL SOC CHEMISTRY | Published : 2021
DOI: 10.1039/d1tb02575a
Abstract
In the fight against drug-resistant pathogenic bacterial and fungal cells, low-dimensional materials are emerging as a promising alternative treatment method. Specifically, few-layer black phosphorus (BP) has demonstrated its effectiveness against a wide range of pathogenic bacterial and fungal cells with studies suggesting low cytotoxicity towards healthy mammalian cells. However, the antimicrobial mechanism of action of BP is not well understood. Before new applications for this material can be realised, further in-depth investigations are required. In this work, the biochemical interaction between BP and a series of microbial cells is investigated using a variety of microscopy and spectro..
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Awarded by RMIT University
Funding Acknowledgements
This work was performed in part at the Micro Nano Research Facility at RMIT University in the Victorian Node of the Australian National Fabrication Facility (ANFF). Facilities and technical support from the RMIT Microscopy and Microanalysis Facility, a node of Microscopy Australia, is acknowledged. This research was undertaken in part on the Infrared microscopy beamline at the Australian Synchrotron, part of ANSTO. Scholarship support from the Australian Postgraduate Award (APA)/Research Training Program (RTP) scheme of the Australian government is acknowledged. We acknowledge equipment funding from the Australian Research Council through LE150100001. The authors would like to acknowledge the kind support on fungal strains from Dr Sarah Kidd from SA Pathology Laboratory. A. E. acknowledges support from the Jack Brockhoff Foundation (JBF Grant number 4655-2019). The Cypher ES AFM instrument was funded in part by Grant LE170100096 from the Australian Research Council (ARC). A. E. acknowledges funding received from the ARC (DE220100511).